ProxAI
AI Generated Protein Binder

DESIGN.
MODULATE.
VALIDATE.

Your knockout takes the whole protein. Your small molecule needs a pocket it can't find. There's a third option. The tool just wasn't available yet.

Institutional Anchors & Collaborators
IRCM
D3
UdeM
&
McGill
Binder Accessibility

There is a tool for your target. Nobody told you.

As a scientist, you might not have been told that engineered protein binders are an option for your research. That is not a gap in your training, it is a gap in how the field communicates.

A protein binder is a precision molecular tool that engages one surface on one protein, letting you disrupt the interaction you have been circling for years without needing a pocket, a knockout, or off-target noise.

Engineered high-affinity binder

You describe the question. You receive
the tool.

One surface. Target the interface directly with no pocket geometry required.

One domain. Silence the function you care about while the rest of your protein stays intact.

Cell validated. Confirmed by a cell-based assay before it reaches your bench, delivered as a research-ready reagent that fits your existing workflow with no new equipment required.

Disrupt the interaction.
Or eliminate the protein.

By exploiting native cellular regulation mechanisms, you can engineer high-precision binders to execute completely distinct therapeutic modalities.

PPI Inhibition
Modulator 01

PPI Inhibition

Direct, high-affinity competitive disruption of targeted protein-protein interaction interfaces. Our binders act as physical shields, shutting down downstream oncogenic signaling across traditionally undruggable flat surfaces.

Applicable Architectures:
Minibinders Cyclic Peptides Nanobodies
Induced Proximity
Modulator 02

Induced Proximity

Bifunctional chimera systems that hijack native cell biology. By mechanically cross-linking your target straight to intracellular degradation machineries, we achieve complete catalytic elimination of the target protein.

Supported Pathways:
bioPROTAC (Proteasomal) LYTAC (Endo-Lysosomal) AUTAC (Autophagy)

We ran it.
Here are the results.

Real-time performance metrics from the ProxAI Engine.
From sequence design to Validated Lead.

100k+ Designs/Cycle
150pM Target KD

Kinetic Benchmark: CDC20

150.4 pM Binding Affinity (KD)
Association 4.2e5
Dissociation 6.3e-5
R-Max 124 RU

Structural Precision

Structural Precision

Comparing AI-Fold to Ground Truth

0.72 Å Mean RMSD
Secure Communication Channel

It starts here.
Your target does the rest.

Connect with our business development and scientific advisory teams.
Submit your details below to schedule an exploratory briefing and initiate mutual NDAs.

Protocol: Encrypted Pre-NDA Channel

Operational HQ

Montreal Clinical Research Institute (IRCM)
IRCM Building - ProxAI Headquarters IRCM Logo

> Wet Lab Infrastructure

Embedded within the prestigious IRCM, our physical laboratory bridges the critical gap between in silico generation and in vitro reality.

> High-Throughput Validation

Rapid, large-scale screening of computationally engineered binders. Executing proprietary validation workflows within native cellular contexts.

> Translational Excellence

Direct integration with top-tier microscopy, genomics, proteomics, immunology, and oncology resources, enabling accelerated development pipelines.